The Yeast APC/C Subunit Mnd2 Prevents Premature Sister Chromatid Separation Triggered by the Meiosis-Specific APC/C-Ama1
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منابع مشابه
The Yeast APC/C Subunit Mnd2 Prevents Premature Sister Chromatid Separation Triggered by the Meiosis-Specific APC/C-Ama1
Cohesion established between sister chromatids during pre-meiotic DNA replication mediates two rounds of chromosome segregation. The first division is preceded by an extended prophase wherein homologous chromosomes undergo recombination. The persistence of cohesion during prophase is essential for recombination and both meiotic divisions. Here we show that Mnd2, a subunit of the anaphase-promot...
متن کاملMnd2, an Essential Antagonist of the Anaphase-Promoting Complex during Meiotic Prophase
Meiotic cohesin serves in sister chromatid linkage and DNA repair until its subunit Rec8 is cleaved by separase. Separase is activated when its inhibitor, securin, is polyubiquitinated by the Cdc20 regulated anaphase-promoting complex (APC(Cdc20)) and consequently degraded. Differently regulated APCs (APC(Cdh1), APC(Ama1)) have not been implicated in securin degradation at meiosis I. We show th...
متن کاملPhosphorylation of the Cohesin Subunit Scc1 by Polo/Cdc5 Kinase Regulates Sister Chromatid Separation in Yeast
At the onset of anaphase, a caspase-related protease (separase) destroys the link between sister chromatids by cleaving the cohesin subunit Scc1. During most of the cell cycle, separase is kept inactive by binding to an inhibitory protein called securin. Separase activation requires proteolysis of securin, which is mediated by an ubiquitin protein ligase called the anaphase-promoting complex. C...
متن کاملPremature separation of sister chromatids in human male meiosis.
BACKGROUND Meiotic disorders result in meiotic arrest and aneuploid spermatozoa, leading to male infertility, spontaneous abortions or affected offspring. We carried out meiotic studies in an infertile male to detect meiotic nondisjunction mechanisms leading to aneuploidy in spermatogenesis. METHODS AND RESULTS Meiotic studies were performed in testicular and semen samples from a 38-year-old ...
متن کاملModifying sister chromatid cohesion for meiosis.
Meiosis produces haploid gametes from diploid cells in two stages that in many ways resemble mitosis. However, the regulatory mechanisms governing kinetochore orientation and cohesion at the first meiotic division are different from those at mitosis: sister kinetochores are pulled forwards from the same spindle pole at metaphase, and centromeric cohesion is protected throughout anaphase. Conseq...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.01.032